primary endothelial cell types, HUVEC, HMVEC and BAEC cells, infected with P. aeruginosa strain PAO1 (PAO1F)
Huber P et al.Sequential inactivation of Rho GTPases and Lim kinase by Pseudomonas aeruginosa toxins ExoS and ExoT leads to endothelial monolayer breakdown
ExoS and ExoT affect cofilin and Lim kinase phosphorylation levels. Cofilin is an actin severing and depolymerization factor that is inactivated by phosphorylation. The infection of HUVEC cells with Pa-WT, Pa-S (PAO1F exoT(-) exoY(-)) or Pa-T (PAO1F exoS(-) exoY(-)) induces a dephosphorylation of cofilin.
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