General Information:

Id: 4,943 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
primary endothelial cell types, HUVEC, HMVEC and BAEC cells, infected with P. aeruginosa strain PAO1 (PAO1F)
article
Reference: Huber P et al.Sequential inactivation of Rho GTPases and Lim kinase by Pseudomonas aeruginosa toxins ExoS and ExoT leads to endothelial monolayer breakdown [PMID: 23974244]

Interaction Information:

Comment ExoS and ExoT affect cofilin and Lim kinase phosphorylation levels. Cofilin is an actin severing and depolymerization factor that is inactivated by phosphorylation. The infection of HUVEC cells with Pa-WT, Pa-S (PAO1F exoT(-) exoY(-)) or Pa-T (PAO1F exoS(-) exoY(-)) induces a dephosphorylation of cofilin.
Formal Description
Interaction-ID: 48862

gene/protein

exoT

decreases_phosphorylation of

gene/protein

CFL1

in primary endothelial cells
Drugbank entries Show/Hide entries for CFL1