General Information:

Id: 4,943 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
primary endothelial cell types, HUVEC, HMVEC and BAEC cells, infected with P. aeruginosa strain PAO1 (PAO1F)
article
Reference: Huber P et al.Sequential inactivation of Rho GTPases and Lim kinase by Pseudomonas aeruginosa toxins ExoS and ExoT leads to endothelial monolayer breakdown [PMID: 23974244]

Interaction Information:

Comment FAK (focal adhesion kinase, PTK2) inactivation was triggered by ExoS and ExoT and paralleled focal adhesion disruption.
Formal Description
Interaction-ID: 48859

gene/protein

exoS

decreases_activity of

gene/protein

PTK2

in primary endothelial cells
Drugbank entries Show/Hide entries for PTK2