General Information:

Id: 4,943 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
primary endothelial cell types, HUVEC, HMVEC and BAEC cells, infected with P. aeruginosa strain PAO1 (PAO1F)
article
Reference: Huber P et al.Sequential inactivation of Rho GTPases and Lim kinase by Pseudomonas aeruginosa toxins ExoS and ExoT leads to endothelial monolayer breakdown [PMID: 23974244]

Interaction Information:

Comment ExoS and ExoT, but not by ExoY induce cell retraction in primary endothelial cells derived from veins (HUVEC), capillaries (HMVEC), and arteries (BAEC), a feature associated with disruption of the actin cytoskeleton and focal adhesions. Quantification of cell retraction shows that Pa-S (PAO1F exoT(-) exoY(-)) was more toxic than Pa-T (PAO1F exoS(-) exoY(-)
Formal Description
Interaction-ID: 48854

gene/protein

exoY

NOT decreases_activity of

in primary endothelial cells
Comment ExoS and ExoT, but not by ExoY induce cell retraction in primary endothelial cells derived from veins (HUVEC), capillaries (HMVEC), and arteries (BAEC), a feature associated with disruption of the actin cytoskeleton and focal adhesions. Quantification of cell retraction shows that Pa-S (PAO1F exoT(-) exoY(-)) was more toxic than Pa-T (PAO1F exoS(-) exoY(-)
Formal Description
Interaction-ID: 48857

gene/protein

exoY

NOT decreases_activity of

in primary endothelial cells
Comment ExoS and ExoT, but not by ExoY induce cell retraction in primary endothelial cells derived from veins (HUVEC), capillaries (HMVEC), and arteries (BAEC), a feature associated with disruption of the actin cytoskeleton and focal adhesions. Quantification of cell retraction shows that Pa-S (PAO1F exoT(-) exoY(-)) was more toxic than Pa-T (PAO1F exoS(-) exoY(-)
Formal Description
Interaction-ID: 48858

gene/protein

exoY

NOT decreases_activity of

in primary endothelial cells