General Information:

Id: 4,942
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
mouse model of acute pneumonia, infected with P. aeruginosa strain PAO1
article
Reference: Golovkine G et al.(2014) VE-Cadherin Cleavage by LasB Protease from Pseudomonas aeruginosa Facilitates Type III Secretion System Toxicity in Endothelial Cells PLoS Pathog. 10 [PMID: 24626230]

Interaction Information:

Comment VE-cadherin (CDH5) levels were strikingly lower in wild-type-infected lungs compared to mock-infected lungs. The infection with strain PAO1-xcpR(-) or PAO1-lasB(-) induced a significantly smaller decrease in VE-cadherin levels, indicating that the P. aeruginosa's T2SS, and more specifically LasB, promoted VE-cadherin degradation in vivo.
Formal Description
Interaction-ID: 48847

gene/protein

lasB

decreases_quantity of

gene/protein

CDH5

in a mouse model of acute pneumonia
Drugbank entries Show/Hide entries for lasB or CDH5