General Information:

Id: 4,941 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0001949 HUVEC cell, infected with P. aeruginosa strain PAO1 or CHA (cystic fibrosis clinical isolate)
article
Reference: Golovkine G et al.(2014) VE-Cadherin Cleavage by LasB Protease from Pseudomonas aeruginosa Facilitates Type III Secretion System Toxicity in Endothelial Cells PLoS Pathog. 10 [PMID: 24626230]

Interaction Information:

Comment The P. aeruginosa T2SS effector, protease LasB , cleaves VE-cadherin (CDH5), a major adhesive protein of interendothelial junctions, as analyzed in human umbilical vein endothelial cells (HUVECs), infected with P. aeruginosa strain PAO1 or CHA (cystic fibrosis clinical isolate).
Formal Description
Interaction-ID: 48845

gene/protein

lasB

decreases_quantity of

gene/protein

CDH5

in infected HUVEC cells
Drugbank entries Show/Hide entries for lasB or CDH5