General Information:

Id: 4,941
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0001949 HUVEC cell, infected with P. aeruginosa strain PAO1 or CHA (cystic fibrosis clinical isolate)
article
Reference: Golovkine G et al.(2014) VE-Cadherin Cleavage by LasB Protease from Pseudomonas aeruginosa Facilitates Type III Secretion System Toxicity in Endothelial Cells PLoS Pathog. 10 [PMID: 24626230]

Interaction Information:

Comment The P. aeruginosa T2SS effector, protease LasB , cleaves VE-cadherin (CDH5), a major adhesive protein of interendothelial junctions, as analyzed in human umbilical vein endothelial cells (HUVECs), infected with P. aeruginosa strain PAO1 or CHA (cystic fibrosis clinical isolate).
Formal Description
Interaction-ID: 48845

gene/protein

lasB

decreases_quantity of

gene/protein

CDH5

in infected HUVEC cells
Drugbank entries Show/Hide entries for lasB or CDH5
Comment The P. aeruginosa T2SS effector, protease LasB , cleaves VE-cadherin (CDH5), a major adhesive protein of interendothelial junctions, as analyzed in human umbilical vein endothelial cells (HUVECs), infected with P. aeruginosa strain PAO1 or CHA (cystic fibrosis clinical isolate).
Formal Description
Interaction-ID: 48846

gene/protein

CDH5

increases_activity of

in endothelial cells
Drugbank entries Show/Hide entries for CDH5
Comment Contrary to its effect on VE-cadherin, P. aeruginosa's secretome did not degrade E-cadherin (CDH1) in epithelial A549 cells. E-cadherin was resistant to LasB, thus indicating that P. aeruginosa-induced epithelial barrier breakdown does not proceed by an analogous mechanism.
Formal Description
Interaction-ID: 48848

gene/protein

lasB

NOT decreases_quantity of

gene/protein

CDH1

in epithelial cells
Drugbank entries Show/Hide entries for lasB