General Information:

Id: 4,659
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain PAO1, treated with physiological concentrations of the human host defense peptide LL-37
article
Reference: Strempel N et al.(2013) Human Host Defense Peptide LL-37 Stimulates Virulence Factor Production and Adaptive Resistance in Pseudomonas aeruginosa PLoS ONE 8 [PMID: 24349231]

Interaction Information:

Comment The authors showed that physiological concentrations of the human host defense peptide cathelicidin LL-37 (CAMP) not only affected the expression of various genes which are involved in quorum sensing cascades and virulence phenotype of P. aeruginosa, but was also able to directly enhance the secretion of toxic metabolites pyocyanin, elastase, PQS and HC.
Formal Description
Interaction-ID: 46377

gene/protein

CAMP

increases_quantity of

drug/chemical compound

Pyocyanine

physiological concentrations of LL-37
Drugbank entries Show/Hide entries for CAMP
Comment The authors showed that physiological concentrations of the human host defense peptide cathelicidin LL-37 (CAMP) not only affected the expression of various genes which are involved in quorum sensing cascades and virulence phenotype of P. aeruginosa, but was also able to directly enhance the secretion of toxic metabolites pyocyanin, elastase, PQS and HC.
Formal Description
Interaction-ID: 46380

gene/protein

CAMP

increases_quantity of

gene/protein

lasB

physiological concentrations of LL-37
Drugbank entries Show/Hide entries for CAMP or lasB
Comment The authors showed that physiological concentrations of the human host defense peptide cathelicidin LL-37 (CAMP) not only affected the expression of various genes which are involved in quorum sensing cascades and virulence phenotype of P. aeruginosa, but was also able to directly enhance the secretion of toxic metabolites pyocyanin, elastase, PQS and HC.
Formal Description
Interaction-ID: 46382

gene/protein

CAMP

increases_quantity of

drug/chemical compound

Hydrogen cyanide

physiological concentrations of LL-37
Drugbank entries Show/Hide entries for CAMP
Comment The authors showed that physiological concentrations of the human host defense peptide cathelicidin LL-37 (CAMP) not only affected the expression of various genes which are involved in quorum sensing cascades and virulence phenotype of P. aeruginosa, but was also able to directly enhance the secretion of toxic metabolites pyocyanin, elastase, PQS and HC.
Formal Description
Interaction-ID: 46384

gene/protein

CAMP

increases_quantity of

drug/chemical compound

2-Heptyl-3-hydroxy-4-quinolone, PQS

physiological concentrations of LL-37
Drugbank entries Show/Hide entries for CAMP
Comment The authors showed that P. aeruginosa resistance to both fluoroquinolone and aminoglycoside antibiotics was enhanced by pre-incubation with the human cathelicidin LL-37 (CAMP.
Formal Description
Interaction-ID: 46385

gene/protein

CAMP

increases_activity of

process

antibiotic resistance

physiological concentrations of LL-37
Drugbank entries Show/Hide entries for CAMP
Comment There is an involvement of the quinolone signal response protein PqsE in the response of P. aeruginosa PAO1 to the human host defense peptide cathelicidin LL-37 (CAMP.
Formal Description
Interaction-ID: 46386

gene/protein

CAMP

affects_activity of

gene/protein

pqsE

physiological concentrations of LL-37
Drugbank entries Show/Hide entries for CAMP