General Information:

Id: 4,642 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
P. aeruginosa strain PA14
Reference: Arts IS et al.(2013) Dissecting the machinery that introduces disulfide bonds in Pseudomonas aeruginosa MBio 4 [PMID: 24327342]

Interaction Information:

Comment The authors analyzed an oxidative protein folding system, consisting of two membrane proteins DsbB1 and DsbB2 that generate disulfide bonds de novo to deliver them to P. aeruginosa DsbA1 (PaDsbA1), a soluble oxidoreductase. PaDsbA1 in turn donates disulfide bonds to secreted proteins, including virulence factors. To analyze exoproteins affected by the impairment of the disulfide formation machinery, the authors identified five proteins that are secreted by the wild type but not by the dsbA1 and dsbB1B2 mutants. These proteins include ImpA, PaAP, CbpD, LasB, PrpL.
Formal Description
Interaction-ID: 46235



affects_folding of



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