General Information:

Id: 4,606
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
THP-1 cells, infected with C. burnetii NMII strain RSA439
article
Reference: Larson CL et al.(2013) Coxiella burnetii effector protein subverts clathrin-mediated vesicular trafficking for pathogen vacuole biogenesis Proc. Natl. Acad. Sci. U.S.A. 110 [PMID: 24248335]

Interaction Information:

Comment CBU0665 (CvpA, Coxiella vacuolar protein A) Is a Dot/Icm T4BSS substrate, as shown in the adenylate cyclase (CyaA) translocation assay in THP-1 cells infected with C. burnetii expressing CyaA-CvpA.
Formal Description
Interaction-ID: 45838

process

T4BSS

increases_transport of

gene/protein

cvpA

shown in a CyaA translocation assay
Comment A C. burnetii delta-cvpA mutant exhibited significant defects in replication and PV development in THP-1 cells. Growth of wild-type C. burnetii and the delta-cvpA mutant was indistinguishable in the axenic medium, ACCM-2.
Formal Description
Interaction-ID: 45843

gene/protein

cvpA

increases_activity of

process

Coxiella burnetii replication

shown in a mutant analysis in THP-1 cells
Comment A C. burnetii delta-cvpA mutant exhibited significant defects in replication and PV development in THP-1 cells. Growth of wild-type C. burnetii and the delta-cvpA mutant was indistinguishable in the axenic medium, ACCM-2.
Formal Description
Interaction-ID: 45844

gene/protein

cvpA

increases_activity of

shown in a mutant analysis in THP-1 cells