General Information:

Id: 4,565 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
LPS (E. coli 055:B5) stimulated mouse RAW264.7 macrophage cells, treated with N-3-oxo-dodecanoyl-l-homoserine lactone (C12)
Reference: Glucksam-Galnoy Y et al.(2013) The bacterial quorum-sensing signal molecule N-3-oxo-dodecanoyl-L-homoserine lactone reciprocally modulates pro- and anti-inflammatory cytokines in activated macrophages J. Immunol. 191: 337-344 [PMID: 23720811]

Interaction Information:

Comment Both N-3-oxo-dodecanoyl-l-homoserine lactone (C12) alone and LPS alone stimulated rapid (15 min) phosphorylation of p38, but only C12 also significantly stimulated p38 phosphorylation over a prolonged time of period of 2 h.
Formal Description
Interaction-ID: 45593

drug/chemical compound


increases_phosphorylation of


p38 MAPK

in RAW264.7 macrophages