General Information:

Id: 4,511
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
human corneal epithelial cells (hTCEpi), infected with P. aeruginosa strain PAO1
article
Reference: Heimer SR et al.(2013) Pseudomonas aeruginosa Utilizes the Type III Secreted Toxin ExoS to Avoid Acidified Compartments within Epithelial Cells PLoS ONE 8 [PMID: 24058462]

Interaction Information:

Comment High exoS transcriptional output coincided with low occupation of acidified vacuoles, and vice versa, for both popB mutants and wild-type bacteria. Translocon (popB) mutants and wild-type bacteria, which can both replicate intracellularly (due to their capacity to secrete ExoS), showed little or no colocalization with acidified vacuoles, compared to the exsA mutant (unable to express ExoS).
Formal Description
Interaction-ID: 45115

gene/protein

exoS

decreases_activity of

Comment Complementation of a triple effector null mutant of PAO1 with exoS (pUCPexoS) reduced the number of acidified bacteria-occupied vacuoles per cell.
Formal Description
Interaction-ID: 45117

gene/protein

exoS

decreases_quantity of

cellular component

acidified bacteria-occupied vacuole

Comment The mechanism by which ExoS ADPr activity allows intracellular replication by P. aeruginosa involves suppression of vacuolar acidification.
Formal Description
Interaction-ID: 45118

gene/protein

exoS

decreases_activity of