General Information:

Id: 4,505 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
different epithelial cell lines, infected with P. aeruginosa strain 6294, PAK, PAO1
Reference: Angus AA et al.(2008) Pseudomonas aeruginosa induces membrane blebs in epithelial cells, which are utilized as a niche for intracellular replication and motility Infect. Immun. 76: 1992-2001 [PMID: 18316391]

Interaction Information:

Comment The type three secretion system (T3SS) of P. aeruginosa was required for membrane blebbing. In the presence of a functional T3SS, wild-type P. aeruginosa was found to localize to membrane blebs, a novel survival niche wherein it demonstrated the capacity for intracellular replication and motility . Mutants lacking either the entire T3SS or specific T3SS components were instead localized to intracellular perinuclear vacuoles as shown by colocalization with the late endosomal/lysosomal marker LAMP-.
Formal Description
Interaction-ID: 45098



increases_activity of


membrane bleb niche formation