General Information:

Id: 4,475 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
Human telomerase-immortalized corneal epithelial cells (hTCEpi), infected with P. aeruginosa strain PAO1
article
Reference: Angus AA et al.(2010) The ADP-ribosylation domain of Pseudomonas aeruginosa ExoS is required for membrane bleb niche formation and bacterial survival within epithelial cells Infect. Immun. 78: 4500-4510 [PMID: 20732998]

Interaction Information:

Comment Mutation of exoS results in loss of bleb niche formation and lack of intracellular replicative capacity. Comparison of mutants that contained multiple-effector deletions revealed that ExoS had the ability to enable bleb niche formation. The bleb niche-forming efficiency of ExoY-expressing PAO1 was low and was not observed for ExoT-expressing PAO1.
Formal Description
Interaction-ID: 45045

gene/protein

exoY

increases_activity of

process

membrane bleb niche formation

in human corneal epithelial cells (hTCEpi); only to a low extend