General Information:

Id: 4,439
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain PAO1
article
Reference: Dong YH et al.(2013) The global regulator Crc plays a multifaceted role in modulation of type III secretion system in Pseudomonas aeruginosa Microbiologyopen 2: 161-172 [PMID: 23292701]

Interaction Information:

Comment Crc positively regulates the expression of exsCEBA. The parental strain PAO1pClacZ (pcZ), which carried a single copy of PexsC-lacZ transcriptional reporter gene on its chromosome and its exsA transposon mutant (exsA::Tn) were used as positive and negative controls, respectively.
Formal Description
Interaction-ID: 44894

gene/protein

crc

increases_expression of

gene/protein

exsA

Comment Disruption of crc impaired the expression of exoT, exsD, and popN.
Formal Description
Interaction-ID: 44905

gene/protein

crc

increases_expression of

gene/protein

exoT

Comment Disruption of crc impaired the expression of exoT, exsD, and popN. Although the proteins ExsD and PopN are known for their negative regulatory role on T3SS, the beta-galactosidase activity assay results showed that the translational expression of both genes was downregulated in the delta-crc mutan.
Formal Description
Interaction-ID: 44916

gene/protein

crc

increases_expression of

gene/protein

exsD

Comment Disruption of crc impaired the expression of exoT, exsD, and popN. Although the proteins ExsD and PopN are known for their negative regulatory role on T3SS, the beta-galactosidase activity assay results showed that the translational expression of both genes was downregulated in the delta-crc mutant.
Formal Description
Interaction-ID: 44917

gene/protein

crc

increases_expression of

gene/protein

popN

Comment Disruption of crc impaired T3SS-dependent cytotoxicity. The authors analysed T3SS-dependent cytotoxicity in human epithelial Hela- and A549 cells, infected with wild-type PAO1 and delta-crc mutant by analysing cell viability. The influence of Crc on T3SS is through its direct or indirect regulatory role on the transcriptional expression of exs.
Formal Description
Interaction-ID: 44919

gene/protein

crc

increases_activity of

process

T3SS

analysing cell viability in infected Hela- and A549 cells
Comment The Cbr/Crc signaling system is involved in the regulation of T3SS in addition to its role in catabolite repression in P. aeruginos.
Formal Description
Interaction-ID: 44923

gene/protein

crc

affects_activity of