General Information:

Id: 4,423 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
THP-1 cells, infected with C. burnetii NMII RSA439
Reference: MacDonald LJ et al.(2012) Coxiella burnetii alters cyclic AMP-dependent protein kinase signaling during growth in macrophages Infect. Immun. 80: 1980-1986 [PMID: 22473604]

Interaction Information:

Comment PKA (cyclic AMP-dependent protein kinase) activity is critical for C. burnetii replication that relies on formation and expansion of the phagolysosome-like PV, as shown by treatment with kinase inhibitors H-89 or Rp-cAMPS that antagonize C. burnetii replication.
Formal Description
Interaction-ID: 44865


Protein kinase A

increases_activity of


Coxiella burnetii replication

in THP-1 cells, infected with avirulent C. burnetii NMII RSA439