General Information:

Id: 4,410 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii / mammalia
human monocytic TH1 cells, infected with C. burnetii (RSA439) NMII
article
Reference: Macdonald LJ et al.Coxiella burnetii exploits host cAMP-dependent protein kinase signalling to promote macrophage survival [PMID: 24028560]

Interaction Information:

Comment C. burnetii uses T4SS secretion system effectors to coordinate PKA-directed signaling at the PV membrane. In a PKA subunit RI localization assay, RI was shown to be was present on -50% of wild type C. burnetii PV at 48 hpi and this trafficking required an active T4SS as only -7% of IcmD mutant-containing phagosomes decorated with RI throughout infection. R1 still localized to the PV membrane in H-89 (PKA inhibitor)-treated cells, further indicating that C. burnetii secretion is not prevented in the presence of H-89.
Formal Description
Interaction-ID: 44856

process

T4BSS

increases_transport of

complex/PPI

Protein kinase A

to the parasitophorous vacuole, PV