General Information:

Id: 4,410 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii / mammalia
human monocytic TH1 cells, infected with C. burnetii (RSA439) NMII
article
Reference: Macdonald LJ et al.Coxiella burnetii exploits host cAMP-dependent protein kinase signalling to promote macrophage survival [PMID: 24028560]

Interaction Information:

Comment cAMP-dependent protein kinase (PKA) activity is required for C. burnetii inhibition of macrophage apoptosis. PKA is activated during infectio.
Formal Description
Interaction-ID: 44825

process

Coxiella burnetii infection

increases_activity of

complex/PPI

Protein kinase A

as shown with the specific inhibitors H-89 and Rp-cAMPS
Comment The results indicate PKA inhibition impairs C. burnetii's capacity to prevent PARP cleavage and protect its host cell from apoptotic death.
Formal Description
Interaction-ID: 44826

process

Coxiella burnetii infection

decreases_processing of

gene/protein

PARP1

Drugbank entries Show/Hide entries for PARP1
Comment Phosphorylated Bad levels increase during C. burnetii infection. Bad is a pro-apoptotic protein regulated by phosphorylation. Densitometry analysis confirmed that the timing of increased Bad phosphorylation corresponds to kinase activation, suggesting Akt is activated first during infection and phosphorylates Bad at Ser136, followed by PKA activation and Bad Ser155 phosphorylation.
Formal Description
Interaction-ID: 44828

process

Coxiella burnetii infection

increases_activity of

increased Ser136 phosphorylation was observed as early as 12 hpi