General Information:

Id: 4,410 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii / mammalia
human monocytic TH1 cells, infected with C. burnetii (RSA439) NMII
article
Reference: Macdonald LJ et al.Coxiella burnetii exploits host cAMP-dependent protein kinase signalling to promote macrophage survival [PMID: 24028560]

Interaction Information:

Comment cAMP-dependent protein kinase (PKA) activity is required for C. burnetii inhibition of macrophage apoptosis. PKA is activated during infectio.
Formal Description
Interaction-ID: 44825

process

Coxiella burnetii infection

increases_activity of

complex/PPI

Protein kinase A

as shown with the specific inhibitors H-89 and Rp-cAMPS