General Information:

Id: 4,337 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
sputum of CF (cystic fribrosis) patients
Reference: Konings AF et al.(2013) Pseudomonas aeruginosa uses multiple pathways to acquire iron during chronic infection in cystic fibrosis lungs Infect. Immun. 81: 2697-2704 [PMID: 23690396]

Interaction Information:

Comment The authors analysed the sputum of CF (cystic fibrosis) patients by RT-qPCR. The expression of the genes hasI and hasR (involved in the heme uptake system) and phuR and phuS (involved in the heme uptake system, Phu) indicated that Pseudomonas heme uptake systems are active in CF patients.
Formal Description
Interaction-ID: 44396


P. aeruginosa infection, chronic

increases_activity of


heme uptake system, Phu

in sputum of most but not all CF patients