General Information:

Id: 4,337 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
sputum of CF (cystic fribrosis) patients
article
Reference: Konings AF et al.(2013) Pseudomonas aeruginosa uses multiple pathways to acquire iron during chronic infection in cystic fibrosis lungs Infect. Immun. 81: 2697-2704 [PMID: 23690396]

Interaction Information:

Comment The authors analysed the sputum of CF (cystic fibrosis) patients by RT-qPCR. Although pyoverdine is known to be an important factor in the survival of P. aeruginosa in CF, the expression levels of the pvd genes (pvdS, pvdH and pvdL), involved in the biosynthesis of pyoverdine, were very low in some samples, consistent with the absence of detectable pyoverdine in some sputum samples. These results suggest that pyoverdine is not absolutely required during chronic infection of the CF airwa.
Formal Description
Interaction-ID: 44355

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

pvdS

in sputum of most but not all CF patients