General Information:

Id: 4,337 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
sputum of CF (cystic fribrosis) patients
article
Reference: Konings AF et al.(2013) Pseudomonas aeruginosa uses multiple pathways to acquire iron during chronic infection in cystic fibrosis lungs Infect. Immun. 81: 2697-2704 [PMID: 23690396]

Interaction Information:

Comment The authors analysed the sputum of CF (cystic fibrosis) patients by RT-qPCR. Although pyoverdine is known to be an important factor in the survival of P. aeruginosa in CF, the expression levels of the pvd genes (pvdS, pvdH and pvdL), involved in the biosynthesis of pyoverdine, were very low in some samples, consistent with the absence of detectable pyoverdine in some sputum samples. These results suggest that pyoverdine is not absolutely required during chronic infection of the CF airwa.
Formal Description
Interaction-ID: 44355

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

pvdS

in sputum of most but not all CF patients
Comment The authors analysed the sputum of CF (cystic fibrosis) patients by RT-qPCR. Although pyoverdine is known to be an important factor in the survival of P. aeruginosa in CF, the expression levels of the pvd genes (pvdS, pvdH and pvdL), involved in the biosynthesis of pyoverdine, were very low in some samples, consistent with the absence of detectable pyoverdine in some sputum samples. These results suggest that pyoverdine is not absolutely required during chronic infection of the CF airwa.
Formal Description
Interaction-ID: 44369

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

pvdH

in sputum of most but not all CF patients
Comment The authors analysed the sputum of CF (cystic fibrosis) patients by RT-qPCR. Although pyoverdine is known to be an important factor in the survival of P. aeruginosa in CF, the expression levels of the pvd genes (pvdS, pvdH and pvdL), involved in the biosynthesis of pyoverdine, were very low in some samples, consistent with the absence of detectable pyoverdine in some sputum samples. These results suggest that pyoverdine is not absolutely required during chronic infection of the CF airwa.
Formal Description
Interaction-ID: 44370

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

pvdL

in sputum of most but not all CF patients
Comment The authors analysed the sputum of CF (cystic fibrosis) patients by RT-qPCR. The expression of pchF (involved in the biosynthesis of pyochelin) was detected in most samples, and pyochelin was detected in some samples, suggesting that pyochelin-mediated iron uptake plays a role in some, but perhaps not all, infections.
Formal Description
Interaction-ID: 44372

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

pchF

in sputum of most but not all CF patients
Drugbank entries Show/Hide entries for pchF
Comment The authors analysed the sputum of CF (cystic fibrosis) patients by RT-qPCR. Although pyoverdine is known to be an important factor in the survival of P. aeruginosa in CF, the expression levels of the pvd genes (pvdS, pvdH and pvdL), involved in the biosynthesis of pyoverdine, were very low in some samples, consistent with the absence of detectable pyoverdine in some sputum samples. These results suggest that pyoverdine is not absolutely required during chronic infection of the CF airwa.
Formal Description
Interaction-ID: 44381

process

P. aeruginosa infection, chronic

affects_quantity of

drug/chemical compound

Pyoverdine I

in sputum of most but not all CF patients
Comment The authors analysed the sputum of CF (cystic fibrosis) patients by RT-qPCR. The expression of pchF (involved in the biosynthesis of pyochelin) was detected in most samples, and pyochelin was detected in some samples, suggesting that pyochelin-mediated iron uptake plays a role in some, but perhaps not all, infections.
Formal Description
Interaction-ID: 44384

process

P. aeruginosa infection, chronic

affects_quantity of

drug/chemical compound

Pyochelin

in sputum of most but not all CF patients
Comment The authors analysed the sputum of CF (cystic fibrosis) patients by RT-qPCR. The expression of the genes hasI and hasR (involved in the heme uptake system) and phuR and phuS (involved in the heme uptake system, Phu) indicated that Pseudomonas heme uptake systems are active in CF patients.
Formal Description
Interaction-ID: 44395

process

P. aeruginosa infection, chronic

increases_activity of

process

heme uptake system, Has

in sputum of most but not all CF patients
Comment The authors analysed the sputum of CF (cystic fibrosis) patients by RT-qPCR. The expression of the genes hasI and hasR (involved in the heme uptake system) and phuR and phuS (involved in the heme uptake system, Phu) indicated that Pseudomonas heme uptake systems are active in CF patients.
Formal Description
Interaction-ID: 44396

process

P. aeruginosa infection, chronic

increases_activity of

process

heme uptake system, Phu

in sputum of most but not all CF patients
Comment The authors analysed the sputum of CF (cystic fibrosis) patients by RT-qPCR. Ferrous ions can be internalized into P. aeruginosa through the inner membrane permease FeoB. In sputum, feoB transcripts were detected in all 53 samples examined.
Formal Description
Interaction-ID: 44397

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

feoB

in sputum of all CF patients