General Information:

Id: 4,283 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
HeLa cells or J774A.1 cells, infected with substrate mutants
Reference: Weber MM et al.(2013) Identification of Coxiella burnetii type IV secretion substrates required for intracellular replication and Coxiella-containing vacuole formation J. Bacteriol. 195: 3914-3924 [PMID: 23813730]

Interaction Information:

Comment The authors showed that 10 T4SS substrate mutants, among 20 mutants analysed, exhibited defects in intracellular growth and CCV formation in HeLa and J774A.1 cells, but displayed normal growth in bacteriological medium. Tn insertion into Cbu0012, Cbu1198, Cbu1457, and Cbu2013 resulted in reduced intracellular replication compared to RSA439 levels.
Formal Description
Interaction-ID: 43943



increases_activity of


Coxiella burnetii replication

in J774A.1 cells