General Information:

Id: 4,283 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
HeLa cells or J774A.1 cells, infected with substrate mutants
Reference: Weber MM et al.(2013) Identification of Coxiella burnetii type IV secretion substrates required for intracellular replication and Coxiella-containing vacuole formation J. Bacteriol. 195: 3914-3924 [PMID: 23813730]

Interaction Information:

Comment The authors showed that 10 T4SS substrate mutants, among 20 mutants analysed, exhibited defects in intracellular growth and CCV formation in HeLa and J774A.1 cells, but displayed normal growth in bacteriological medium. Six substrate mutants (Cbu0041, Cbu0388, Cbu0425, Cbu0937, Cbu2052, and Cbu2059) were unable to replicate in J774A.1 cells or HeLa cells. Due to their role in intracellular replication and CCV formation, Cbu0041, Cbu0425, Cbu0937, Cbu2052, and Cbu2059 were renamed to cirA, cirB, cirC, cirD, and cirE (Coxiella effector for intracellular replication), respectively.
Formal Description
Interaction-ID: 43913



increases_activity of


Coxiella burnetii replication

in HeLa and J774A.1 cells
Drugbank entries Show/Hide entries for cirA