General Information:

Id: 4,265 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
mouse embryonic fibroblasts, MEFs, challenged withN-(3-oxododecanoyl)-HSL (C12)
Reference: Valentine CD et al.(2013) X-Box Binding Protein 1 (XBP1s) Is a Critical Determinant of Pseudomonas aeruginosa Homoserine Lactone-Mediated Apoptosis PLoS Pathog. 9 [PMID: 23990788]

Interaction Information:

Comment Both Ire1-alpha(-/-) and Xbp1(-/-) MEFs are resistant to C12 (N-(3-oxododecanoyl)-HSL) cytotoxicity. The phosphorylation of p-eIF2-alpha and p-p38 MAPK does not contribute greatly to C12-mediated cell death in MEFs. The inhibition of p38 MAPK activity (using SB203580 or SB202190) did not inhibit C12 cytotoxicity or caspase 3/7 activation in wt MEFs.
Formal Description
Interaction-ID: 43591


p38 MAPK

NOT increases_activity of



in mouse embryonic fibroblasts; in response to N-(3-oxododecanoyl)-HSL (C12)
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