General Information:

Id: 4,202
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
P. aeruginosa strain PAO1
article
Reference: Longo F et al.(2013) A New Transcriptional Repressor of the Pseudomonas aeruginosa Quorum Sensing Receptor Gene lasR PLoS ONE 8 [PMID: 23861975]

Interaction Information:

Comment PA3699 acts as a novel repressor of lasR transcription and of P. aeruginosa virulence factors production. The authors showed that there is a direct molecular interaction between PA3699 and the lasR promoter region.
Formal Description
Interaction-ID: 43107

gene/protein

PA3699

decreases_expression of

gene/protein

lasR

analysed by DNA-affinity chromatography and EMSA assays
Drugbank entries Show/Hide entries for lasR
Comment The production of LasR-dependent phenotypes such as elastase, pyocyanin, and proteases was strongly decreased in P. aeruginosa upon PA3699 induction.
Formal Description
Interaction-ID: 43125

gene/protein

PA3699

decreases_quantity of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasB
Comment The production of LasR-dependent phenotypes such as elastase, pyocyanin, and proteases was strongly decreased in P. aeruginosa upon PA3699 induction.
Formal Description
Interaction-ID: 43127

gene/protein

PA3699

decreases_quantity of

drug/chemical compound

Pyocyanine