General Information:

Id: 4,081 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
J774 Eclone macrophages, infected with live or heat-inactivated P. aeruginosa strain PAO1 or PA103
article
Reference: Mustafi S et al.(2013) Regulation of Rab5 Function during Phagocytosis of Live Pseudomonas aeruginosa in Macrophages Infect. Immun. 81: 2426-2436 [PMID: 23630954]

Interaction Information:

Comment It has been shown that inhibition of J774-Eclone phagocytosis by ExoS-producing strain PAO1 occurs in conjunction with inhibition of Rab5 activation, while inhibition of phagocytosis by ExoT-producing PA103 strains occurs independently of alterations in Rab5 activation.
Formal Description
Interaction-ID: 42110

gene/protein

exoT

NOT decreases_activity of

gene/protein

RAB5

Comment It has been shown that inhibition of J774-Eclone phagocytosis by ExoS-producing strain PAO1 occurs in conjunction with inhibition of Rab5 activation, while inhibition of phagocytosis by ExoT-producing PA103 strains occurs independently of alterations in Rab5 activation.
Formal Description
Interaction-ID: 42118

gene/protein

exoT

decreases_activity of

process

phagocytosis

during the internalization of live (to a larger extend) or heat-inactivated P. aeruginosa