General Information:

Id: 4,081 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
J774 Eclone macrophages, infected with live or heat-inactivated P. aeruginosa strain PAO1 or PA103
article
Reference: Mustafi S et al.(2013) Regulation of Rab5 Function during Phagocytosis of Live Pseudomonas aeruginosa in Macrophages Infect. Immun. 81: 2426-2436 [PMID: 23630954]

Interaction Information:

Comment Exotoxin S (ExoS) has been shown to play a critical role in Rab5 activation during phagocytosis of P. aeruginosa. The inactivation of Rab5 was dependent on ExoS ADP-ribosyltransferase activity, and in J744-Eclone cells, ExoS ADP-ribosyltransferase activity caused a more severe inhibition of phagocytosis than ExoS Rho GTPase activity.
Formal Description
Interaction-ID: 42099

gene/protein

exoS

decreases_activity of

process

phagocytosis

during the internalization of live (to a larger extend) or heat-inactivated P. aeruginosa