General Information:

Id: 4,001 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
C57BL/6 NE-/- mice and their wild-type (WT) littermates, infected with P. aeruginosa strain H103
article
Reference: Benabid R et al.(2012) Neutrophil elastase modulates cytokine expression: contribution to host defense against Pseudomonas aeruginosa-induced pneumonia J. Biol. Chem. 287 [PMID: 22927440]

Interaction Information:

Comment In a mouse model of Pseudomonas aeruginosa-induced pneumonia it has been shown both in in vivo and cell culture studies that active NE (neutrophil elastase) induces mRNA expression of TNF-alpha, MIP-2, and IL-6 resulting in the increase of their protein levels.
Formal Description
Interaction-ID: 40995

gene/protein

ELANE

increases_quantity of

gene/protein

TNF

in cell free BALs (bronchoalveolar lavage), in J774 murine macrophages and in whole lung tissues; in response to P. aeruginosa infection
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