General Information:

Id: 4,001
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
C57BL/6 NE-/- mice and their wild-type (WT) littermates, infected with P. aeruginosa strain H103
article
Reference: Benabid R et al.(2012) Neutrophil elastase modulates cytokine expression: contribution to host defense against Pseudomonas aeruginosa-induced pneumonia J. Biol. Chem. 287 [PMID: 22927440]

Interaction Information:

Comment In a mouse model of Pseudomonas aeruginosa-induced pneumonia it has been shown both in in vivo and cell culture studies that active NE (neutrophil elastase) induces mRNA expression of TNF-alpha, MIP-2, and IL-6 resulting in the increase of their protein levels.
Formal Description
Interaction-ID: 40993

gene/protein

ELANE

increases_expression of

gene/protein

TNF

in cell free BALs (bronchoalveolar lavage), in J774 murine macrophages and in whole lung tissues; in response to P. aeruginosa infection
Drugbank entries Show/Hide entries for ELANE or TNF
Comment In a mouse model of Pseudomonas aeruginosa-induced pneumonia it has been shown both in in vivo and cell culture studies that active NE (neutrophil elastase) induces mRNA expression of TNF-alpha, MIP-2, and IL-6 resulting in the increase of their protein levels.
Formal Description
Interaction-ID: 40995

gene/protein

ELANE

increases_quantity of

gene/protein

TNF

in cell free BALs (bronchoalveolar lavage), in J774 murine macrophages and in whole lung tissues; in response to P. aeruginosa infection
Drugbank entries Show/Hide entries for ELANE or TNF
Comment In a mouse model of Pseudomonas aeruginosa-induced pneumonia it has been shown both in in vivo and cell culture studies that active NE (neutrophil elastase) induces mRNA expression of TNF-alpha, MIP-2, and IL-6 resulting in the increase of their protein levels.
Formal Description
Interaction-ID: 40997

gene/protein

ELANE

increases_expression of

gene/protein

CXCL2

in cell free BALs (bronchoalveolar lavage), in J774 murine macrophages and in whole lung tissues; in response to P. aeruginosa infection
Drugbank entries Show/Hide entries for ELANE
Comment In a mouse model of Pseudomonas aeruginosa-induced pneumonia it has been shown both in in vivo and cell culture studies that active NE (neutrophil elastase) induces mRNA expression of TNF-alpha, MIP-2, and IL-6 resulting in the increase of their protein levels.
Formal Description
Interaction-ID: 40998

gene/protein

ELANE

increases_quantity of

gene/protein

CXCL2

in cell free BALs (bronchoalveolar lavage), in J774 murine macrophages and in whole lung tissues; in response to P. aeruginosa infection
Drugbank entries Show/Hide entries for ELANE
Comment In a mouse model of Pseudomonas aeruginosa-induced pneumonia it has been shown both in in vivo and cell culture studies that active NE (neutrophil elastase) induces mRNA expression of TNF-alpha, MIP-2, and IL-6 resulting in the increase of their protein levels.
Formal Description
Interaction-ID: 40999

gene/protein

ELANE

increases_expression of

gene/protein

IL6

in cell free BALs (bronchoalveolar lavage), in J774 murine macrophages and in whole lung tissues; in response to P. aeruginosa infection
Drugbank entries Show/Hide entries for ELANE or IL6
Comment In a mouse model of Pseudomonas aeruginosa-induced pneumonia it has been shown both in in vivo and cell culture studies that active NE (neutrophil elastase) induces mRNA expression of TNF-alpha, MIP-2, and IL-6 resulting in the increase of their protein levels.
Formal Description
Interaction-ID: 41001

gene/protein

ELANE

increases_quantity of

gene/protein

IL6

in cell free BALs (bronchoalveolar lavage), in J774 murine macrophages and in whole lung tissues; in response to P. aeruginosa infection
Drugbank entries Show/Hide entries for ELANE or IL6
Comment Increased levels of active NE (neutrophil elastase) in cell-free BALs parallel neutrophil Influx during P. aeruginosa-induced Pneumonia.
Formal Description
Interaction-ID: 41002

increases_quantity of

gene/protein

ELANE

in cell free BALs (bronchoalveolar lavage); in response to P. aeruginosa infection
Drugbank entries Show/Hide entries for ELANE
Comment Increased levels of active NE (neutrophil elastase) in cell-free BALs parallel neutrophil Influx during P. aeruginosa-induced Pneumonia.
Formal Description
Interaction-ID: 41004

process

P. aeruginosa infection

increases_activity of

in cell free BALs (bronchoalveolar lavage) and in whole lung tissues
Comment The implication of NE (neutrophil elastase) in the induction of cytokine expression involved at least in part Toll-like receptor 4 (TLR-4). The results suggest the contribution of NE and potentially other enzymes to TLR-4 proteolysis.
Formal Description
Interaction-ID: 41007

gene/protein

ELANE

affects_activity of

gene/protein

TLR4

Drugbank entries Show/Hide entries for ELANE or TLR4
Comment The implication of NE (neutrophil elastase) in the induction of cytokine expression involved at least in part Toll-like receptor 4 (TLR-4). The results suggest the contribution of NE and potentially other enzymes to TLR-4 proteolysis.
Formal Description
Interaction-ID: 41010

gene/protein

ELANE

decreases_quantity of

gene/protein

TLR4

Drugbank entries Show/Hide entries for ELANE or TLR4