General Information:

Id: 3,961 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
human monocytic THP-1 cells, infected with P. aeruginosa strain PA14
article
Reference: Van Alst NE et al.(2009) Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa Infect. Immun. 77: 4446-4454 [PMID: 19651860]

Interaction Information:

Comment Addition of exogenous nitric oxide (NO)-generating compounds to delta-nirS mutant cultures restored the production of T3SS phospholipase ExoU, whereas nitrite addition had no effect. These results suggest that NO generated via nitrite reductase NirS contributes to the regulation of expression of selected virulence factors in P. aeruginosa PA14.
Formal Description
Interaction-ID: 40266

drug/chemical compound

NO

increases_activity of

process

T3SS