human monocytic THP-1 cells, infected with P. aeruginosa strain PA14
Van Alst NE et al.(2009) Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa Infect. Immun. 77: 4446-4454
Addition of exogenous nitric oxide (NO)-generating compounds to delta-nirS mutant cultures restored the production of T3SS phospholipase ExoU, whereas nitrite addition had no effect. These results suggest that NO generated via nitrite reductase NirS contributes to the regulation of expression of selected virulence factors in P. aeruginosa PA14.
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