General Information:

Id: 3,961 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
human monocytic THP-1 cells, infected with P. aeruginosa strain PA14
article
Reference: Van Alst NE et al.(2009) Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa Infect. Immun. 77: 4446-4454 [PMID: 19651860]

Interaction Information:

Comment The authors show that both membrane nitrate reductase and nitrite reductase enzyme complexes are important for virulence during the interaction of P. aeruginosa PA14 with THP-1 cells. Deletion mutations in genes encoding membrane nitrate reductase (delta-narGH) and nitrite reductase (delta-nirS) were killed to a significantly greater degree than wild-type PA14 in the THP-1 cell-P. aeruginosa coculture.
Formal Description
Interaction-ID: 40257

gene/protein

nirS

increases_quantity of

drug/chemical compound

NO

Drugbank entries Show/Hide entries for nirS