General Information:

Id: 3,961 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
human monocytic THP-1 cells, infected with P. aeruginosa strain PA14
Reference: Van Alst NE et al.(2009) Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa Infect. Immun. 77: 4446-4454 [PMID: 19651860]

Interaction Information:

Comment The authors show that both membrane nitrate reductase and nitrite reductase enzyme complexes are important for virulence during the interaction of P. aeruginosa PA14 with THP-1 cells. Deletion mutations in genes encoding membrane nitrate reductase (delta-narGH) and nitrite reductase (delta-nirS) were killed to a significantly greater degree than wild-type PA14 in the THP-1 cell-P. aeruginosa coculture.
Formal Description
Interaction-ID: 40257



increases_quantity of

drug/chemical compound


Drugbank entries Show/Hide entries for nirS
Comment Addition of exogenous nitric oxide (NO)-generating compounds to delta-nirS mutant cultures restored the production of T3SS phospholipase ExoU, whereas nitrite addition had no effect. These results suggest that NO generated via nitrite reductase NirS contributes to the regulation of expression of selected virulence factors in P. aeruginosa PA14.
Formal Description
Interaction-ID: 40266

drug/chemical compound


increases_activity of