General Information:

Id: 3,959
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
P. aeruginosa strain PAO1
article
Reference: Michel GP et al.(2007) XphA/XqhA, a novel GspCD subunit for type II secretion in Pseudomonas aeruginosa J. Bacteriol. 189: 3776-3783 [PMID: 17351035]

Interaction Information:

Comment The XphA/XqhA pair substitutes for the XcpP/XcpQ pair and constitutes a secretion subunit (the P(A)Q(A) subunit) not genetically linked to the classical Xcp system. XphA and XqhA are responsible for the residual secretion observed in the xcpP/xcpQ double mutant. It has been shown that the P(A)Q(A) subunit requires the presence of XcpR-Z as additional secretion components to constitute a functional hybrid T2SS secretory apparatus.
Formal Description
Interaction-ID: 40189

gene/protein

xphA

is_part_of

complex/PPI

T2SS (hybrid-Xcp)-associated complexes

Comment The XphA/XqhA pair substitutes for the XcpP/XcpQ pair and constitutes a secretion subunit (the P(A)Q(A) subunit) not genetically linked to the classical Xcp system. XphA and XqhA are responsible for the residual secretion observed in the xcpP/xcpQ double mutant. It has been shown that the P(A)Q(A) subunit requires the presence of XcpR-Z as additional secretion components to constitute a functional hybrid T2SS secretory apparatus.
Formal Description
Interaction-ID: 40190

gene/protein

xqhA

is_part_of

complex/PPI

T2SS (hybrid-Xcp)-associated complexes

Comment The XphA/XqhA pair substitutes for the XcpP/XcpQ pair and constitutes a secretion subunit (the P(A)Q(A) subunit) not genetically linked to the classical Xcp system. XphA and XqhA are responsible for the residual secretion observed in the xcpP/xcpQ double mutant. It has been shown that the P(A)Q(A) subunit requires the presence of XcpR-Z as additional secretion components to constitute a functional hybrid T2SS secretory apparatus.
Formal Description
Interaction-ID: 40191

complex/PPI

T2SS (hybrid-Xcp)-associated complexes

increases_activity of

Comment The results showed that except for the aminopeptidase PaAP, for which secretion is not restored by the P(A)Q(A) subunit in the xcpP/xcpQ deletion mutant, each major Xcp-dependent exoprotein (CbpD, LasB, PrpL) is secreted by the new hybrid machinery.
Formal Description
Interaction-ID: 40192

increases_transport of

gene/protein

cpbD

Comment The results showed that except for the aminopeptidase PaAP, for which secretion is not restored by the P(A)Q(A) subunit in the xcpP/xcpQ deletion mutant, each major Xcp-dependent exoprotein (CbpD, LasB, PrpL) is secreted by the new hybrid machinery.
Formal Description
Interaction-ID: 40193

increases_transport of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasB
Comment The results showed that except for the aminopeptidase PaAP, for which secretion is not restored by the P(A)Q(A) subunit in the xcpP/xcpQ deletion mutant, each major Xcp-dependent exoprotein (CbpD, LasB, PrpL) is secreted by the new hybrid machinery.
Formal Description
Interaction-ID: 40194

increases_transport of

gene/protein

prpL

Comment The results showed that except for the aminopeptidase PaAP, for which secretion is not restored by the P(A)Q(A) subunit in the xcpP/xcpQ deletion mutant, each major Xcp-dependent exoprotein (CbpD, LasB, PrpL) is secreted by the new hybrid machinery.
Formal Description
Interaction-ID: 40195

NOT increases_transport of

gene/protein

paaP