General Information:

Id: 3,953 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
mouse model of acute pneumonia
lungs of mice, infected with P. aeruginosa clinical isolate PA99
article
Reference: Howell HA et al.(2013) Type III secretion of ExoU is critical during early Pseudomonas aeruginosa pneumonia MBio 4 [PMID: 23481600]

Interaction Information:

Comment The authors used qRT-PCR to demonstrate that the exoU gene of P. aeruginosa is rapidly (within 4.5 h postinfection) induced in the lungs of mice during acute pneumonia.
Formal Description
Interaction-ID: 40125

disease

Acute pneumonia

increases_expression of

gene/protein

exoU

from 3 h postinfection to 12 h postinfection
Comment The rapid increase in exoU transcript levels early during acute pneumonia is also accompanied by rapid production of ExoU protein, as shown by ExoU fluorescence.
Formal Description
Interaction-ID: 40128

disease

Acute pneumonia

increases_quantity of

gene/protein

exoU

from 3 h postinfection to 12 h postinfection
Comment The exoU gene, encoding the highly cytotoxic type III effector ExoU, is induced early during acute P. aeruginosa pneumonia.
Formal Description
Interaction-ID: 40131

process

T3SS

increases_transport of

gene/protein

exoU