General Information:

Id: 3,942 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
COS-7 cells or EBC-1 cells, infected with P. aeruginosa strain PAO1-derived recombinant protein (rEprS)
Reference: Kida Y et al.(2013) EprS, an autotransporter protein of Pseudomonas aeruginosa, possessing serine protease activity induces inflammatory responses through protease-activated receptors Cell. Microbiol. 15: 1168-1181 [PMID: 23311922]

Interaction Information:

Comment The proteolytic activity of EprS is required for activation of PAR-1, -2 and -4. Co-transfection of COS-7 cells with human PAR-1, -2 and -4 expression plasmids activated NF-kappa-B-driven promoter in response to stimulation with rEprS WT in a dose-dependent manner.
Formal Description
Interaction-ID: 40037



increases_activity of

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