General Information:

Id: 3,942
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
COS-7 cells or EBC-1 cells, infected with P. aeruginosa strain PAO1-derived recombinant protein (rEprS)
article
Reference: Kida Y et al.(2013) EprS, an autotransporter protein of Pseudomonas aeruginosa, possessing serine protease activity induces inflammatory responses through protease-activated receptors Cell. Microbiol. 15: 1168-1181 [PMID: 23311922]

Interaction Information:

Comment The proteolytic activity of EprS is required for activation of PAR-1, -2 and -4. Co-transfection of COS-7 cells with human PAR-1, -2 and -4 expression plasmids activated NF-kappa-B-driven promoter in response to stimulation with rEprS WT in a dose-dependent manner.
Formal Description
Interaction-ID: 40032

gene/protein

eprS

increases_activity of

gene/protein

F2R

Drugbank entries Show/Hide entries for eprS or F2R
Comment The proteolytic activity of EprS is required for activation of PAR-1, -2 and -4. Co-transfection of COS-7 cells with human PAR-1, -2 and -4 expression plasmids activated NF-kappa-B-driven promoter in response to stimulation with rEprS WT in a dose-dependent manner.
Formal Description
Interaction-ID: 40035

gene/protein

eprS

increases_activity of

gene/protein

F2RL1

Drugbank entries Show/Hide entries for eprS
Comment The proteolytic activity of EprS is required for activation of PAR-1, -2 and -4. Co-transfection of COS-7 cells with human PAR-1, -2 and -4 expression plasmids activated NF-kappa-B-driven promoter in response to stimulation with rEprS WT in a dose-dependent manner.
Formal Description
Interaction-ID: 40036

gene/protein

eprS

increases_activity of

gene/protein

F2RL3

Drugbank entries Show/Hide entries for eprS
Comment The proteolytic activity of EprS is required for activation of PAR-1, -2 and -4. Co-transfection of COS-7 cells with human PAR-1, -2 and -4 expression plasmids activated NF-kappa-B-driven promoter in response to stimulation with rEprS WT in a dose-dependent manner.
Formal Description
Interaction-ID: 40037

gene/protein

F2R

increases_activity of

Drugbank entries Show/Hide entries for F2R
Comment The proteolytic activity of EprS is required for activation of PAR-1, -2 and -4. Co-transfection of COS-7 cells with human PAR-1, -2 and -4 expression plasmids activated NF-kappa-B-driven promoter in response to stimulation with rEprS WT in a dose-dependent manner.
Formal Description
Interaction-ID: 40038

gene/protein

F2RL1

increases_activity of

Comment The proteolytic activity of EprS is required for activation of PAR-1, -2 and -4. Co-transfection of COS-7 cells with human PAR-1, -2 and -4 expression plasmids activated NF-kappa-B-driven promoter in response to stimulation with rEprS WT in a dose-dependent manner.
Formal Description
Interaction-ID: 40039

gene/protein

F2RL3

increases_activity of

Comment EprS has the ability to induce IL-8 production through PAR-2 in EBC-1 cells (human bronchiole epithelial cell line.
Formal Description
Interaction-ID: 40040

gene/protein

F2RL1

increases_quantity of

gene/protein

CXCL8

Comment P. aeruginosa EprS is a serine protease and is annotated as an autotransporter protein. The type V secretion system (T5SS) comprises diverse branches, the autotransporter (AT or type Va and type Vc) pathway and two-partner secretion (TPS or type Vb) pathway. P. aeruginosa is able to secrete the endogenous EprS passenger domain into the extracellular environment.
Formal Description
Interaction-ID: 40042

process

T5aSS

increases_transport of

gene/protein

eprS

into the extracellular environment
Drugbank entries Show/Hide entries for eprS
Comment The results indicate that EprS require PARs to activate NF-kappa-B, thereby modulating host inflammatory and immune responses such as cytokine production.
Formal Description
Interaction-ID: 40046

increases_activity of

Comment The results indicate that EprS require PARs to activate NF-kappa-B, thereby modulating host inflammatory and immune responses such as cytokine production.
Formal Description
Interaction-ID: 40051

increases_activity of

process

immune response