General Information:

Id: 3,902
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
P. aeruginosa strain PA14 grown with GlcNAc as the primary carbon and energy source
article
Reference: Korgaonkar AK and Whiteley M(2011) Pseudomonas aeruginosa enhances production of an antimicrobial in response to N-acetylglucosamine and peptidoglycan J. Bacteriol. 193: 909-917 [PMID: 21169497]

Interaction Information:

Comment N-acetylglucosamine (GlcNAc) can serve as carbon and energy source. The analysis of P. aeruginosa gene expression during growth on GlcNAc revealed that genes annotated to play a role in GlcNAc catabolism were induced between 27- and 34-fold. These genes are organized in the nag operon, including nagR, nagA, glmS, nagF and nagE.
Formal Description
Interaction-ID: 39573

drug/chemical compound

N-Acetyl-D-glucosamine

increases_expression of

gene/protein

nagR

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine
Comment N-acetylglucosamine (GlcNAc) can serve as carbon and energy source. The analysis of P. aeruginosa gene expression during growth on GlcNAc revealed that genes annotated to play a role in GlcNAc catabolism were induced between 27- and 34-fold. These genes are organized in the nag operon, including nagR, nagA, glmS, nagF and nagE.
Formal Description
Interaction-ID: 39574

gene/protein

nagR

increases_activity of

Comment N-acetylglucosamine (GlcNAc) can serve as carbon and energy source. The analysis of P. aeruginosa gene expression during growth on GlcNAc revealed that genes annotated to play a role in GlcNAc catabolism were induced between 27- and 34-fold. These genes are organized in the nag operon, including nagR, nagA, glmS, nagF and nagE.
Formal Description
Interaction-ID: 39575

drug/chemical compound

N-Acetyl-D-glucosamine

increases_expression of

gene/protein

nagA

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine or nagA
Comment N-acetylglucosamine (GlcNAc) can serve as carbon and energy source. The analysis of P. aeruginosa gene expression during growth on GlcNAc revealed that genes annotated to play a role in GlcNAc catabolism were induced between 27- and 34-fold. These genes are organized in the nag operon, including nagR, nagA, glmS, nagF and nagE.
Formal Description
Interaction-ID: 39577

gene/protein

nagA

increases_activity of

Drugbank entries Show/Hide entries for nagA
Comment N-acetylglucosamine (GlcNAc) can serve as carbon and energy source. The analysis of P. aeruginosa gene expression during growth on GlcNAc revealed that genes annotated to play a role in GlcNAc catabolism were induced between 27- and 34-fold. These genes are organized in the nag operon, including nagR, nagA, glmS, nagF and nagE.
Formal Description
Interaction-ID: 39578

drug/chemical compound

N-Acetyl-D-glucosamine

increases_expression of

gene/protein

glmS

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine or glmS
Comment N-acetylglucosamine (GlcNAc) can serve as carbon and energy source. The analysis of P. aeruginosa gene expression during growth on GlcNAc revealed that genes annotated to play a role in GlcNAc catabolism were induced between 27- and 34-fold. These genes are organized in the nag operon, including nagR, nagA, glmS, nagF and nagE.
Formal Description
Interaction-ID: 39579

gene/protein

glmS

increases_activity of

Drugbank entries Show/Hide entries for glmS
Comment N-acetylglucosamine (GlcNAc) can serve as carbon and energy source. The analysis of P. aeruginosa gene expression during growth on GlcNAc revealed that genes annotated to play a role in GlcNAc catabolism were induced between 27- and 34-fold. These genes are organized in the nag operon, including nagR, nagA, glmS, nagF and nagE.
Formal Description
Interaction-ID: 39580

drug/chemical compound

N-Acetyl-D-glucosamine

increases_expression of

gene/protein

nagF

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine
Comment N-acetylglucosamine (GlcNAc) can serve as carbon and energy source. The analysis of P. aeruginosa gene expression during growth on GlcNAc revealed that genes annotated to play a role in GlcNAc catabolism were induced between 27- and 34-fold. These genes are organized in the nag operon, including nagR, nagA, glmS, nagF and nagE.
Formal Description
Interaction-ID: 39581

gene/protein

nagF

increases_activity of

Comment N-acetylglucosamine (GlcNAc) can serve as carbon and energy source. The analysis of P. aeruginosa gene expression during growth on GlcNAc revealed that genes annotated to play a role in GlcNAc catabolism were induced between 27- and 34-fold. These genes are organized in the nag operon, including nagR, nagA, glmS, nagF and nagE.
Formal Description
Interaction-ID: 39582

drug/chemical compound

N-Acetyl-D-glucosamine

increases_expression of

gene/protein

nagE

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine
Comment N-acetylglucosamine (GlcNAc) can serve as carbon and energy source. The analysis of P. aeruginosa gene expression during growth on GlcNAc revealed that genes annotated to play a role in GlcNAc catabolism were induced between 27- and 34-fold. These genes are organized in the nag operon, including nagR, nagA, glmS, nagF and nagE.
Formal Description
Interaction-ID: 39583

gene/protein

nagE

increases_activity of

Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39584

drug/chemical compound

N-Acetyl-D-glucosamine

increases_expression of

gene/protein

phzC2

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine
Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39585

gene/protein

phzC2

is_part_of

complex/PPI

phz2-operon

Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39586

drug/chemical compound

N-Acetyl-D-glucosamine

increases_expression of

gene/protein

phzD2

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine
Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39587

gene/protein

phzD2

is_part_of

complex/PPI

phz2-operon

Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39588

drug/chemical compound

N-Acetyl-D-glucosamine

increases_expression of

gene/protein

phzE2

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine
Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39589

gene/protein

phzE2

is_part_of

complex/PPI

phz2-operon

Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39590

drug/chemical compound

N-Acetyl-D-glucosamine

increases_expression of

gene/protein

phzF2

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine
Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39591

gene/protein

phzF2

is_part_of

complex/PPI

phz2-operon

Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39592

drug/chemical compound

N-Acetyl-D-glucosamine

increases_expression of

gene/protein

phzG2

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine
Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39593

gene/protein

phzG2

is_part_of

complex/PPI

phz2-operon

Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39594

drug/chemical compound

N-Acetyl-D-glucosamine

increases_expression of

gene/protein

phzA1

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine
Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39595

gene/protein

phzA1

is_part_of

complex/PPI

phz1-operon

Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39596

drug/chemical compound

N-Acetyl-D-glucosamine

increases_expression of

gene/protein

phzB1

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine
Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39597

gene/protein

phzB1

is_part_of

complex/PPI

phz1-operon

Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39598

drug/chemical compound

N-Acetyl-D-glucosamine

increases_expression of

gene/protein

lasA

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine
Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 39599

drug/chemical compound

N-Acetyl-D-glucosamine

increases_expression of

gene/protein

lasB

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine or lasB
Comment Extraction of the phenazine pyocyanin revealed that the addition of glucose or succinate had no effect on pyocyanin levels, while the addition of GlcNAc resulted in a significant increase in pyocyanin levels, showing that P. aeruginosa increases the production of the antimicrobial pyocyanin in the presence of N-acetylglucosamine (GlcNAc).
Formal Description
Interaction-ID: 39600

drug/chemical compound

N-Acetyl-D-glucosamine

increases_quantity of

drug/chemical compound

Pyocyanine

in P. aeruginosa, grown with GlcNAc as the primary carbon and energy source
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine
Comment To assess whether a GlcNAc-containing polymer could also affect pyocyanin levels, P. aeruginosa grown in MOPS medium containing 20 mM succinate was supplemented with insoluble S. aureus peptidoglycan and pyocyanin levels quantified. WT P. aeruginosa grown in the presence of peptidoglycan displayed a significant increase in pyocyanin, indicating that P. aeruginosa increases the production of an antimicrobial in the presence of extracellular peptidoglycan.
Formal Description
Interaction-ID: 39602

cellular component

peptidoglycan, exogenous

increases_quantity of

drug/chemical compound

Pyocyanine

in P. aeruginosa, treated with insoluble S. aureus peptidoglycan
Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 40313

gene/protein

phzG2

is_part_of

complex/PPI

phz2-operon

Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 40314

complex/PPI

phz2-operon

increases_quantity of

drug/chemical compound

Phenazine-1-carboxylic acid

Comment In addition to genes putatively involved in N-acetylglucosamine (GlcNAc) catabolism, genes encoding factors important for killing eukaryotic and prokaryotic cells were induced during growth with GlcNAc as the primary carbon and energy source. These genes are involved in phenazine biosynthesis, as well as genes encoding the extracellular proteases LasA and LasB.
Formal Description
Interaction-ID: 40315

complex/PPI

phz1-operon

increases_quantity of

drug/chemical compound

Phenazine-1-carboxylic acid