General Information:

Id: 3,900
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/heterologous host
P. aeruginosa strain PA14, treated with peptidoglycan
article
Reference: Korgaonkar A et al.(2013) Community surveillance enhances Pseudomonas aeruginosa virulence during polymicrobial infection Proc. Natl. Acad. Sci. U.S.A. 110: 1059-1064 [PMID: 23277552]

Interaction Information:

Comment The addition of GlcNAc (N-acetylglucosamine) and the GlcNAc-containing polymer peptidoglycan (exogenous peptidoglycan, originating from commensal Gram-positive bacteria) to P. aeruginosa results in enhanced production of the virulence factors pyocyanin, elastase and Pseudomonas quinolone signal, PQS (2-heptyl-3-hydroxy-4-quinolone).
Formal Description
Interaction-ID: 39552

drug/chemical compound

N-Acetyl-D-glucosamine

increases_quantity of

gene/protein

lasB

in P. aeruginosa
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine or lasB
Comment The addition of GlcNAc (N-acetylglucosamine) and the GlcNAc-containing polymer peptidoglycan (exogenous peptidoglycan, originating from commensal Gram-positive bacteria) to P. aeruginosa results in enhanced production of the virulence factors pyocyanin, elastase and Pseudomonas quinolone signal, PQS (2-heptyl-3-hydroxy-4-quinolone).
Formal Description
Interaction-ID: 39553

cellular component

peptidoglycan, exogenous

increases_quantity of

gene/protein

lasB

in P. aeruginosa
Drugbank entries Show/Hide entries for lasB
Comment The addition of GlcNAc (N-acetylglucosamine) and the GlcNAc-containing polymer peptidoglycan (exogenous peptidoglycan, originating from commensal Gram-positive bacteria) to P. aeruginosa results in enhanced production of the virulence factors pyocyanin, elastase and Pseudomonas quinolone signal, PQS (2-heptyl-3-hydroxy-4-quinolone).
Formal Description
Interaction-ID: 39554

drug/chemical compound

N-Acetyl-D-glucosamine

increases_quantity of

drug/chemical compound

Pyocyanine

in P. aeruginosa
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine
Comment The addition of GlcNAc (N-acetylglucosamine) and the GlcNAc-containing polymer peptidoglycan (exogenous peptidoglycan, originating from commensal Gram-positive bacteria) to P. aeruginosa results in enhanced production of the virulence factors pyocyanin, elastase and Pseudomonas quinolone signal, PQS (2-heptyl-3-hydroxy-4-quinolone).
Formal Description
Interaction-ID: 39555

cellular component

peptidoglycan, exogenous

increases_quantity of

drug/chemical compound

Pyocyanine

in P. aeruginosa
Comment The addition of GlcNAc (N-acetylglucosamine) and the GlcNAc-containing polymer peptidoglycan (exogenous peptidoglycan, originating from commensal Gram-positive bacteria) to P. aeruginosa results in enhanced production of the virulence factors pyocyanin, elastase and Pseudomonas quinolone signal, PQS (2-heptyl-3-hydroxy-4-quinolone).
Formal Description
Interaction-ID: 39556

drug/chemical compound

N-Acetyl-D-glucosamine

increases_quantity of

drug/chemical compound

2-Heptyl-3-hydroxy-4-quinolone, PQS

in P. aeruginosa
Drugbank entries Show/Hide entries for N-Acetyl-D-glucosamine
Comment The addition of GlcNAc (N-acetylglucosamine) and the GlcNAc-containing polymer peptidoglycan (exogenous peptidoglycan, originating from commensal Gram-positive bacteria) to P. aeruginosa results in enhanced production of the virulence factors pyocyanin, elastase and Pseudomonas quinolone signal, PQS (2-heptyl-3-hydroxy-4-quinolone).
Formal Description
Interaction-ID: 39557

cellular component

peptidoglycan, exogenous

increases_quantity of

drug/chemical compound

2-Heptyl-3-hydroxy-4-quinolone, PQS

in P. aeruginosa
Comment The P. aeruginosa gene PA0601 (PA14_07840) is required for GlcNAc and peptidoglycan sensing in P. aeruginosa. Inactivation of this gene did not affect production of PQS-controlled virulence factors during monoculture growth but eliminated enhanced production of these factors in the presence of GlcNAc or peptidoglycan.
Formal Description
Interaction-ID: 39558

gene/protein

PA14_07840

affects_activity of

drug/chemical compound

N-Acetyl-D-glucosamine

in P. aeruginosa
Drugbank entries Show/Hide entries for
Comment The P. aeruginosa gene PA0601 (PA14_07840) is required for GlcNAc and peptidoglycan sensing in P. aeruginosa. Inactivation of this gene did not affect production of PQS-controlled virulence factors during monoculture growth but eliminated enhanced production of these factors in the presence of GlcNAc or peptidoglycan.
Formal Description
Interaction-ID: 39559

gene/protein

PA14_07840

affects_activity of

cellular component

peptidoglycan, exogenous

in P. aeruginosa