General Information:

Id: 3,868 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
C57BL/6J mice or human lung microvascular endothelial cells (HLMVECs), infected with P. aeruginosa strain PA103
article
Reference: Fu P et al.(2013) Role of nicotinamide adenine dinucleotide phosphate-reduced oxidase proteins in Pseudomonas aeruginosa-induced lung inflammation and permeability Am. J. Respir. Cell Mol. Biol. 48: 477-488 [PMID: 23306835]

Interaction Information:

Comment Unlike NOX2(-/-) (CYBB-/-) mice, knockdown of NOX4 inhibited P. aeruginosa-induced pulmonary permeability as evidenced by BAL (bronchoalveolar lavage) fluids cell count and protein concentration. On the contrary, knockdown of NOX4 had no effects on IL-6, TNF-alpha and H2O2 in BAL fluids.
Formal Description
Interaction-ID: 38941

gene/protein

NOX4

NOT affects_quantity of

gene/protein

TNF

in BAL fluids of mice
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