General Information:

Id: 3,866
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
HaCat cells, induced with (S)-3-oxo-C12-HSL (N-(3-oxododecanoyl)-homoserine lactone)
article
Reference: von Hoven G et al.(2012) Modulation of translation and induction of autophagy by bacterial exoproducts Med. Microbiol. Immunol. 201: 409-418 [PMID: 22991039]

Interaction Information:

Comment (S)-3-oxo-C12-HSL (N-(3-oxododecanoyl)-HSL) triggered eIF2-alpha-phosphorylation in HaCat cells.
Formal Description
Interaction-ID: 38862

drug/chemical compound

N-(3-Oxododecanoyl)-HSL

increases_phosphorylation of

gene/protein

EIF2S1

Comment (S)-3-oxo-C12-HSL (N-(3-oxododecanoyl)-HSL) did not cause phosphorylation of eIF2-alpha-kinase GCN2 (EIF2AK4), but led to the phosphorylation of eIF2-alpha-kinase PKR (EIF2AK2).
Formal Description
Interaction-ID: 38865

drug/chemical compound

N-(3-Oxododecanoyl)-HSL

increases_phosphorylation of

gene/protein

EIF2AK2

Comment (S)-3-oxo-C12-HSL (N-(3-oxododecanoyl)-HSL) did not cause phosphorylation of eIF2-alpha-kinase GCN2 (EIF2AK4), but led to the phosphorylation of eIF2-alpha-kinase PKR (EIF2AK2).
Formal Description
Interaction-ID: 38867

gene/protein

EIF2AK2

increases_phosphorylation of

gene/protein

EIF2S1

Comment (S)-3-oxo-C12-HSL (N-(3-oxododecanoyl)-HSL) did not cause phosphorylation of eIF2-alpha-kinase GCN2 (EIF2AK4), but led to the phosphorylation of eIF2-alpha-kinase PKR (EIF2AK2).
Formal Description
Interaction-ID: 38868

drug/chemical compound

N-(3-Oxododecanoyl)-HSL

NOT increases_phosphorylation of

gene/protein

EIF2AK4

Comment (S)-3-oxo-C12-HSL (N-(3-oxododecanoyl)-HSL) did not cause phosphorylation of eIF2-alpha-kinase GCN2 (EIF2AK4), but led to the phosphorylation of eIF2-alpha-kinase PKR (EIF2AK2).
Formal Description
Interaction-ID: 38869

gene/protein

EIF2AK4

increases_phosphorylation of

gene/protein

EIF2S1

Comment Activation of p38 was also markedly reduced after knockdown of PKR (EIF2AK2).
Formal Description
Interaction-ID: 38871

gene/protein

EIF2AK2

increases_phosphorylation of

gene/protein

p38 MAPK

Comment Activation of p38 was also markedly reduced after knockdown of PKR (EIF2AK2).
Formal Description
Interaction-ID: 38872

gene/protein

EIF2AK2

increases_activity of

gene/protein

p38 MAPK

Comment Metabolic labeling experiments revealed that (S)-3-oxo-C12-HSL (N-(3-oxododecanoyl)-HSL) inhibits translation.
Formal Description
Interaction-ID: 38873

drug/chemical compound

N-(3-Oxododecanoyl)-HSL

decreases_activity of

process

translation

Comment (S)-3-oxo-C12-HSL (N-(3-oxododecanoyl)-HSL) impacts autophagy. Higher levels of LC3II (lipidated LC3, a marker of autophagy) were observed following treatment with alpha-toxin of S. aureus or (S)-3-oxo-C12-HSL of P. aeruginosa, and in both cases, this effect was enhanced by bafilomycin.
Formal Description
Interaction-ID: 38874

drug/chemical compound

N-(3-Oxododecanoyl)-HSL

increases_activity of

process

autophagy