General Information:

Id: 3,862 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
HeLa cells, infected with P. aeruginisa strain (GESPA 1999 collection)
article
Reference: Gendrin C et al.(2012) Structural basis of cytotoxicity mediated by the type III secretion toxin ExoU from Pseudomonas aeruginosa PLoS Pathog. 8 [PMID: 22496657]

Interaction Information:

Comment Ubiquitinated ExoU is targeted to endosomes. Ub-ExoU-S142A (catalytically-inactive mutant) did not co-localize with endoplasmic reticulum nor with Golgi markers, but was targeted to acidic organelles, as evidenced by its co-localization with the early endosome marker EEA1 and with lysotracker-stained compartments.
Formal Description
Interaction-ID: 38818

gene/protein

exoU

is localized in

cellular component

early endosome

the ubiquitinated form of ExoU