General Information:

Id: 3,862 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
HeLa cells, infected with P. aeruginisa strain (GESPA 1999 collection)
Reference: Gendrin C et al.(2012) Structural basis of cytotoxicity mediated by the type III secretion toxin ExoU from Pseudomonas aeruginosa PLoS Pathog. 8 [PMID: 22496657]

Interaction Information:

Comment The non-catalytic mutant ExoU-S142A also displays a strong affinity for PI(4,5)P2, but this interaction is completely abolished in the case of a mutant lacking residues 679-683, which suggests a direct role of PI(4,5)P2 interaction for ExoU PM (plasma membrane) localization. These results thus provide a molecular explanation for ExoU's PM targeting, which constitutes the toxin's premier localization upon T3SS translocation.
Formal Description
Interaction-ID: 38816



is localized in

cellular component

host cell plasma membrane