General Information:

Id: 3,858
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
epithelial cell monolayers of MDCK or Caco-2 cells, infected with P. aeruginosa strain PAO1 delta-pvdE/pvdE or delta-pvdE/exoS
article
Reference: Okuda J et al.(2012) Complementation of the exoS gene in the pvdE pyoverdine synthesis gene-deficient mutant of Pseudomonas aeruginosa results in recovery of the pvdE gene-mediated penetration through the intestinal epithelial cell barrier but not the pvdE-mediated virulence in silkworms J. Infect. Chemother. 18: 332-340 [PMID: 22080193]

Interaction Information:

Comment The pvdE gene is essential for pyoverdine (PVD) production. The pvdE gene knockout strain, delta-pvdE, showed significantly reduced PVD (pyoverdine) production as compared with the wild-type strain and pvdE-complemented delta-pvdE strain (the delta-pvdE/pvdE strain).
Formal Description
Interaction-ID: 38758

gene/protein

pvdE

increases_quantity of

drug/chemical compound

Pyoverdine I

Comment The authors regard the ability of P. aeruginosa to penetrate epithelial cell monolayers as a virulence factor. The knockout of the PVD synthesis gene pvdE caused a great decrease in the ability of the bacterium to penetrate epithelial cell monolayers.
Formal Description
Interaction-ID: 38765

gene/protein

pvdE

increases_activity of

of P.aeruginosa into host
Comment The expression of the exoS gene is associated with the pvdE gene-mediated penetration of P. aeruginosa through intestinal epithelial cell monolayers. The exoS gene mRNA expression in the delta-pvdE strain was greatly decreased, compared to the wild-type strain. The expression of other type III-related genes (exoT, exoY, and pscF) in the delta-pvdE strain was not influenced. The exoS-complemented delta-pvdE strain (delta-pvdE/exoS) showed recovery in bacterial penetration ability through epithelial cell monolayers.
Formal Description
Interaction-ID: 38768

gene/protein

pvdE

increases_expression of

gene/protein

exoS

Comment The expression of the exoS gene is associated with the pvdE gene-mediated penetration of P. aeruginosa through intestinal epithelial cell monolayers. The exoS gene mRNA expression in the delta-pvdE strain was greatly decreased, compared to the wild-type strain. The expression of other type III-related genes (exoT, exoY, and pscF) in the delta-pvdE strain was not influenced. The exoS-complemented delta-pvdE strain (delta-pvdE/exoS) showed recovery in bacterial penetration ability through epithelial cell monolayers.
Formal Description
Interaction-ID: 38771

gene/protein

exoS

increases_activity of

of P.aeruginosa into host