General Information:

Id: 3,838 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
foreskin-derived primary keratinocytes, infected with supernatants from P. aeruginosa CF391 grown in PG (1% peptone-1% glucose) medium or LB (lysogeny broth) medium
article
Reference: Dossel J et al.(2012) Pseudomonas aeruginosa-derived rhamnolipids subvert the host innate immune response through manipulation of the human beta-defensin-2 expression Cell. Microbiol. 14: 1364-1375 [PMID: 22500651]

Interaction Information:

Comment Rhamnolipids manipulate the flagellin- and IL-1-beta induced hBD-2 release but not the flagellin-induced IL-8 release in keratinocytes. Flagellin induced the release of IL-8 in keratinocytes, but in contrast to hBD-2, co-incubation of rhamnolipids did not diminish the flagellin-induced IL-8 release significantly.
Formal Description
Interaction-ID: 38566

gene/protein

fliC

increases_quantity of

gene/protein

CXCL8

in keratinocytes
Comment Rhamnolipids manipulate the flagellin- and IL-1-beta induced hBD-2 release but not the flagellin-induced IL-8 release in keratinocytes. Flagellin induced the release of IL-8 in keratinocytes, but in contrast to hBD-2, co-incubation of rhamnolipids did not diminish the flagellin-induced IL-8 release significantly.
Formal Description
Interaction-ID: 38567

cellular component

rhamnolipid

NOT affects_quantity of

gene/protein

CXCL8

in keratinocytes