General Information:

Id: 3,827 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Damron FH and Goldberg JB(2012) Proteolytic regulation of alginate overproduction in Pseudomonas aeruginosa Mol. Microbiol. 84: 595-607 [PMID: 22497280]

Interaction Information:

Comment Expression of the alginate machinery and biosynthetic enzymes are controlled by the extracytoplasmic sigma factor, sigma-22 (AlgU/T). The key negative regulator of both sigma-22 activity and the mucoid phenotype is the cognate anti-sigma factor MucA. MucA sequesters sigma-22 to the inner membrane inhibiting the sigma factor's transcriptional activity.
Formal Description
Interaction-ID: 38285

gene/protein

mucA

decreases_activity of

gene/protein

algU