General Information:

Id: 3,822 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
HL-60 derived human macrophages, infected with L. pneumophila WT strain JR32 (Icm/Dot secretion system), expressing Cya fusions to the indicated C. burnetii proteins
Reference: Lifshitz Z et al.(2013) Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal Proc. Natl. Acad. Sci. U.S.A. 110: E707-E715 [PMID: 23382224]

Interaction Information:

Comment The authors analysed six hypothetical C. burnetii proteins that has been translocated into host cells in an Icm/Dot-dependent manner. These effector-encoding genes were found to be expressed, as shown by qPCR with C. burnetii grown in axenic media, as well as in vivo in HEK 293T cells. They showed a similar expression pattern as two previously identified C. burnetii effectors, coxDFB1 and CBU2056.
Formal Description
Interaction-ID: 38251



increases_transport of



shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus