General Information:

Id: 3,816 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
DHCR24(-/-) mouse embryonic fibroblasts (-cholesterol MEFs), or supplemented with cholesterol (+cholesterol MEFs)
Reference: Gilk SD et al.(2013) Bacterial colonization of host cells in the absence of cholesterol PLoS Pathog. 9 [PMID: 23358892]

Interaction Information:

Comment For the three bacteria C. burnetii, S. Typhimurium or C. trachomatis, no notable difference in vacuole size or morphology was observed between -cholesterol and +cholesterol MEFs. Growth assays revealed no significant differences in overall bacterial replication, showing that intracellular replication is independent of cholesterol.
Formal Description
Interaction-ID: 38187

drug/chemical compound

host cell cholesterol

NOT affects_activity of


Coxiella burnetii replication

as shown in -cholesterol/+cholesterol MEFs (mouse embryonic fibroblasts)