General Information:

Id: 3,810 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
HeLa cells, siRNA treated, infected with C. burnetii NMII, producing BlaM-77 fusion protein
article
Reference: McDonough JA et al.(2013) Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening MBio 4 [PMID: 23362322]

Interaction Information:

Comment The depletion of the retromer associated sorting nexins SNX2, SNX3, SNX5, SNX6 resulted in reduced BlaM-77 translocation. This shows that the retromer and most associated sorting nexins play important roles in stages of CCV maturation that are important for effector translocation.
Formal Description
Interaction-ID: 38164

gene/protein

SNX6

increases_activity of

process

T4BSS

in C. burnetii infected HeLa cells; analysed by treatment with SNX6 siRNA and the BlaM translocation assay