General Information:

Id: 3,806 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
C57BL/6 mice derived bone marrow macrophages (BMMs), infected with C. burnetii NMII producing BlaM-effector fusion proteins BlaM alone, BlaM-77, BlaM-1823, BlaM-1524
article
Reference: Newton HJ et al.(2013) Effector Protein Translocation by the Coxiella burnetii Dot/Icm Type IV Secretion System Requires Endocytic Maturation of the Pathogen-Occupied Vacuole PLoS ONE 8 [PMID: 23349930]

Interaction Information:

Comment Effector translocation by C. burnetii was efficiently blocked when the pH of intracellular organelles was neutralized by treating BMMs with BafA (Bafilomycin A) during infection.
Formal Description
Interaction-ID: 37941

increases_activity of

process

T4BSS

in C. burnetii infected BMMs