General Information:

Id: 3,806 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
C57BL/6 mice derived bone marrow macrophages (BMMs), infected with C. burnetii NMII producing BlaM-effector fusion proteins BlaM alone, BlaM-77, BlaM-1823, BlaM-1524
article
Reference: Newton HJ et al.(2013) Effector Protein Translocation by the Coxiella burnetii Dot/Icm Type IV Secretion System Requires Endocytic Maturation of the Pathogen-Occupied Vacuole PLoS ONE 8 [PMID: 23349930]

Interaction Information:

Comment As shown in HeLa cells, assays in BMMs (bone marrow derived macrophages) determined that the three different BlaM-effector fusions (CBU0077, CBU1823 and CBU1524 (caeA)) were translocated during infection by C. burnetii. In BMMs there were a small number of translocation-positive cells detected at four hours post-infection for all three effector proteins, which suggests that the Dot/Icm system is activated sooner following uptake by BMMs.
Formal Description
Interaction-ID: 37938

process

T4BSS

increases_transport of

gene/protein

CBU_1823

into BMMs; detected at four hours post-infection, shown in a BlaM translocation assay